Effect of Volatile Oil of Radix Angelicae Sinensis on experimental asthma in rats / 中国应用生理学杂志
Chinese Journal of Applied Physiology
;
(6): 107-110, 2015.
Artigo
em Chinês
| WPRIM
| ID: wpr-243407
ABSTRACT
<p><b>OBJECTIVE</b>To study the effects of Volatile Oil of Radix Angelicae Sinensis (VOA) on experimental asthma in rat model based on abnormal immune functions of Treg cells.</p><p><b>METHODS</b>After grouping, the asthmatic rats were developed through injecting OVA and AI(OH)3 for sensitization and then administering OVA aerosol for challenge, and the respiratory functions, asthmatic behaviors, IL-10 levels in bronchoalveolar lavage fluid (BALF) (ELISA) and Foxp3 expression (immunohistochemistry) in lung of asthmatic rats were observed.</p><p><b>RESULTS</b>VOA at the doses of 40-160 mg/kg could improve the respiratory functions and the asthmatic behaviors, and upgrade IL-10 levels in BALF and Foxp3 expression in lung of asthmatic rats.</p><p><b>CONCLUSION</b>VOA has some effects of anti-asthma and one of the mechanisms is to improving the lower immune functions of Treg cells.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Asma
/
Óleos de Plantas
/
Óleos Voláteis
/
Líquido da Lavagem Broncoalveolar
/
Química
/
Interleucina-10
/
Linfócitos T Reguladores
/
Angelica sinensis
/
Biologia Celular
Tipo de estudo:
Estudo prognóstico
Limite:
Animais
Idioma:
Chinês
Revista:
Chinese Journal of Applied Physiology
Ano de publicação:
2015
Tipo de documento:
Artigo
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