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Role of HCN channels in the nervous system: membrane excitability and various modulations / 中国应用生理学杂志
Chinese Journal of Applied Physiology ; (6): 506-510, 2014.
Artigo em Chinês | WPRIM | ID: wpr-243419
ABSTRACT
Hyperpolarization-activated and cyclic nucleotide-gated (HCN) channels, distributing in a variety of tissues, especially in excitable cells such as heart cells and many kinds of neurons, have an important role in the modulation of heart rate and neuronal excitability. Different from typical voltage-gated sodium channels and potassium channels, HCN channels were evoked inward currents when the cell was hyperpolarized. More and more recent studies have disclosed that HCN channels play important roles in the nervous system, which were linked with its special electrophysiological features as well as its regulatory effect on the cellular membrane excitability. HCN channels could be modulated by many factors including both extracellular molecules and intracellular signaling cascades, which made its functions complicated in the different condition. Based on its role, HCN channels are presumed to be a promising target for chronic pain and brain disorders. In this paper, we will focus on the advancement of roles of HCN channels in the neural system as well as its complex modulator factors.
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Fisiologia / Canais de Potássio / Canais de Cátion Regulados por Nucleotídeos Cíclicos / Canais Disparados por Nucleotídeos Cíclicos Ativados por Hiperpolarização / Potenciais da Membrana / Neurônios Limite: Humanos Idioma: Chinês Revista: Chinese Journal of Applied Physiology Ano de publicação: 2014 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Fisiologia / Canais de Potássio / Canais de Cátion Regulados por Nucleotídeos Cíclicos / Canais Disparados por Nucleotídeos Cíclicos Ativados por Hiperpolarização / Potenciais da Membrana / Neurônios Limite: Humanos Idioma: Chinês Revista: Chinese Journal of Applied Physiology Ano de publicação: 2014 Tipo de documento: Artigo