Studies on association of HSL repeat polymorphism and aerobic endurance / 中国应用生理学杂志
Chinese Journal of Applied Physiology
;
(6): 93-96, 2015.
Artigo
em Chinês
| WPRIM
| ID: wpr-243423
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the relationship between hormone sensitive lipase (HSL) gene polymorphism and aerobic endurance.</p><p><b>METHODS</b>The (CA)n repeats polymorphism genotypes in HSL intro 6 of 123 outstanding long distance runners and 127 controls of Han nationality in northern China were analyzed by PCR and Fluorescence labeled STR-genescan. Repeat polymorphisms were grouped according to segmentation point and alleles were divided into long or short chains. Chi-square test was used to analyze the frequency difference of allelic and genotypic between athlete and control groups.</p><p><b>RESULTS</b>(CA) n repeats polymorphism in HSL gene was total of 9 different repeat number of alleles, which composed of 25 different genotypes. The chi-square test result showed that when compared short and long chain alleles split by 4, there was a significant difference (P <0.05) of genotype distribution in 5/10 km group compared with control. Compared the rest groups with control, there was no significant difference.</p><p><b>CONCLUSION</b>Compared short and long chain alleles split by 4, the LL genotype of (CA)n of HSL was associated with aerobic endurance and it might be a molecular marker of elite 5/10 km long distance runners.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Resistência Física
/
Polimorfismo Genético
/
Etnicidade
/
China
/
Reação em Cadeia da Polimerase
/
Esterol Esterase
/
Alelos
/
Genética
/
Genótipo
Limite:
Humanos
País/Região como assunto:
Ásia
Idioma:
Chinês
Revista:
Chinese Journal of Applied Physiology
Ano de publicação:
2015
Tipo de documento:
Artigo
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