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Relationship between cyclin G1 and human papilloma virus infection in cervical intraepithelial neoplasia and cervical carcinoma / 中国医学科学杂志(英文版)
Chinese Medical Sciences Journal ; (4): 81-85, 2006.
Artigo em Inglês | WPRIM | ID: wpr-243613
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the overexpression of cyclin G1 in cervical intraepithelial neoplasia (CIN) and cervical carcinoma, and the correlation between cyclin G1 and high-risk human papilloma virus (HPV) infection.</p><p><b>METHODS</b>All of the specimens were obtained from the Department of Pathology of China-Japan Friendship Hospital from January 2000 to August 2004. We detected the expression of cyclin G1 with immunohistochemistry, HPV16/18 infection with in situ hybridization, and high-risk HPV infection with Hybrid capture system II (HC-II) in normal group (25 cases), CIN I (48 cases), CIN II (56 cases), CIN III (54 cases), and invasive cervical squamous-cell carcinoma (SCC, 31 cases).</p><p><b>RESULTS</b>The positive rates of cyclin G1 expression in CIN (77.85%) and SCC cervical tissues (87.10%) were significantly higher than normal (8.00%, P < 0.01), and the intensities of cyclin G1 expression in CIN (40.60%) and SCC cervical tissues (61.51%) were significantly higher than normal (2.72%, P < 0.05). The positive rates and intensities of cyclin G1 expression increased gradually with the grade of cervical lesions. High-risk HPV infection rates were higher in CIN and SCC than normal groups (P < 0.05). There was a positive correlation between cyclin G1 expression and high-risk HPV infection detected with HC-II (Kendall's tau-b = 0.316, 0.269, 0.352, and 0.474 in CIN I, CINII, CIN III, and SCC, respectively, P < 0.05).</p><p><b>CONCLUSIONS</b>Cyclin G1 is overexpressed in CIN and SCC. Cyclin G1 may be a biomarker for detecting CIN and SCC. Cyclin G1 may play an important role in the oncogenesis of CIN and SCC by high-risk HPV infection.</p>
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Virologia / Imuno-Histoquímica / Carcinoma de Células Escamosas / Estudos de Casos e Controles / Displasia do Colo do Útero / Neoplasias do Colo do Útero / Hibridização In Situ / Ciclinas / Infecções por Papillomavirus / Papillomavirus Humano 16 Tipo de estudo: Estudo observacional / Fatores de risco Limite: Feminino / Humanos Idioma: Inglês Revista: Chinese Medical Sciences Journal Ano de publicação: 2006 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Virologia / Imuno-Histoquímica / Carcinoma de Células Escamosas / Estudos de Casos e Controles / Displasia do Colo do Útero / Neoplasias do Colo do Útero / Hibridização In Situ / Ciclinas / Infecções por Papillomavirus / Papillomavirus Humano 16 Tipo de estudo: Estudo observacional / Fatores de risco Limite: Feminino / Humanos Idioma: Inglês Revista: Chinese Medical Sciences Journal Ano de publicação: 2006 Tipo de documento: Artigo