Detection of gene mutations of SCN5A in 7 patients with Brugada syndrome / 中华心血管病杂志
Chinese Journal of Cardiology
;
(12): 404-407, 2008.
Artigo
em Chinês
| WPRIM
| ID: wpr-243770
ABSTRACT
<p><b>OBJECTIVE</b>Brugada syndrome is linked to sodium channel mutations and could induce arrhythmias that even lead to sudden death. The purpose of this study was to detect if there was gene mutation of SCN5A in 7 patients with Brugada syndrome and explore the molecular genetic characteristics of this disease.</p><p><b>METHOD</b>Genomic DNA was extracted from peripheral blood of all 7 patients with Brugada syndrome and 41 pairs of PCR primers were designed to amplify all the 28 exons of SCN5A.</p><p><b>RESULT</b>There was no novel mutation in exons of Gene SCN5A in these patients with Brugada syndrome.</p><p><b>CONCLUSION</b>Brugada syndrome might associated gene mutation or other mechanisms independent of SCN5A gene mutation.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Análise Mutacional de DNA
/
Canais de Sódio
/
Éxons
/
Síndrome de Brugada
/
Genética
/
Proteínas Musculares
/
Mutação
Tipo de estudo:
Estudo diagnóstico
Limite:
Adulto
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Cardiology
Ano de publicação:
2008
Tipo de documento:
Artigo
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