Clinical implication of microvasculopathy in patients post heart transplantation / 中华心血管病杂志
Chinese Journal of Cardiology
; (12): 156-159, 2011.
Article
em Zh
| WPRIM
| ID: wpr-244033
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>Assess the clinical implication of microvasculopathy detected by endomyocardial biopsy samples in patients post heart transplantation.</p><p><b>METHODS</b>Light microscopic evaluations were performed in 278 endomyocardial biopsies harvested from 64 patients post heart transplantation for more than one year, microvasculopathy was defined as stenotic endothelial and/or medial disease.</p><p><b>RESULTS</b>The patients with stenotic microvasculopathy were younger than those without microvasculopathy (40.7 ± 15.9 vs. 49.4 ± 8.7, P < 0.05). The mean score of acute cellular rejection (0.83 ± 0.39 vs. 0.37 ± 0.32, P < 0.01) and the numbers of ≥ grade II acute rejection (0.84 ± 0.16 vs. 0.23 ± 0.10, P < 0.01) were significantly greater in stenotic microvasculopathy group compared to those of non-stenotic group. Multivariate regression analysis confirmed that stenotic microvasculopathy is the independent risk factor for the mean acute rejection score (OR = 3.40, 95%CI, 4.62 - 193.07, P < 0.01), but not for the Quilty lesion, coronary heart disease of donor, diabetes mellitus. Angiographically confirmed coronary vasculopathy and cardiac dysfunction (χ(2) = 0.94, P > 0.05 and χ(2) = 2.90, P > 0.05) were similar between microvasculopathy group and non-microvasculopathy group.</p><p><b>CONCLUSION</b>Post heart transplantation microvasculopathy is an immune-mediated phenomenon and associated with higher mean score of acute cellular rejection and higher numbers of ≥ grade II acute rejection but was not the prognostic risk factor for coronary vasculopathy and function reduction after heart transplantation.</p>
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Índice:
WPRIM
Assunto principal:
Patologia
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Prognóstico
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Cirurgia Geral
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Fatores de Risco
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Transplante de Coração
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Doença das Coronárias
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Endocárdio
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Oclusão de Enxerto Vascular
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Rejeição de Enxerto
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Miocárdio
Tipo de estudo:
Etiology_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Adolescent
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Adult
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Female
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Humans
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Male
Idioma:
Zh
Revista:
Chinese Journal of Cardiology
Ano de publicação:
2011
Tipo de documento:
Article