The Role of Metabotropic Glutamate Receptors in Psychomotor Stimulant Addiction / 대한정신약물학회지
Korean Journal of Psychopharmacology
; : 143-148, 2006.
Article
em Ko
| WPRIM
| ID: wpr-24421
Biblioteca responsável:
WPRO
ABSTRACT
For many years, determining the role of dopamine has been the major focus of the drug abuse research. New evidence, however, suggests that glutamate may play more important roles in the process of development of addictive behaviors. Metabotropic glutamate receptors are abundant in the brain and known to consist of three different groups of subtypes. Experimental data apparently show that they, especially group I and II, have important roles in the process of behaviors indicative of addiction such as locomotor activity, behavioral sensitization, conditioned place preference by psychomotor stimulants, and self-administration of these drugs. Although it has not been yet discovered how they differentially regulate neuronal processes to produce addictive behaviors, they have been suggested as a new possible therapeutic target for the treatment of drug addiction.
Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Encéfalo
/
Dopamina
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Comportamento Aditivo
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Receptores de Glutamato Metabotrópico
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Ácido Glutâmico
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Transtornos Relacionados ao Uso de Substâncias
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Atividade Motora
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Neurônios
Idioma:
Ko
Revista:
Korean Journal of Psychopharmacology
Ano de publicação:
2006
Tipo de documento:
Article