Study on the strategy of Japanese encephalitis immunization using live attenuated vaccine combined with inactivated vaccine / 中华流行病学杂志
Chinese Journal of Epidemiology
;
(12): 113-115, 2003.
Artigo
em Chinês
| WPRIM
| ID: wpr-244222
ABSTRACT
<p><b>OBJECTIVE</b>Using the advantages of Japanese encephalitis live attenuated and inactivated vaccine, to reduce the rate of immunization reaction and to increase the effect, we conducted a study on the strategy of immunization in Japanese encephalitis using live attenuated vaccine combined with inactivated vaccine.</p><p><b>METHODS</b>Observing the safety and immune effects of different groups.</p><p><b>RESULTS</b>Data on side effect showed that the rate of moderate and severe systematic reactions of the group who were inoculated with combined vaccine was 0.73%, with local reaction 1.46% while the combined rate of moderate and severe systematic reaction of the group who were inoculated with inactivated vaccine was 2.8%. Under the detection of serum neutralizing antibody, the GMT rose from 11.05 - 13.35 before vaccination to 147.34 - 1101.30 after vaccination in the different groups. Neutralizing antibody was detected in 97.67% of the combined group. There was a significant difference by comparing neutralizing antibody seroconversion rate of the combined group with the inactivated group (chi(2) = 3.89, P < 0.05), but no significant difference with attenuated group (chi(2) = 0.74, P > 0.05).</p><p><b>CONCLUSION</b>Results showed that in children who previously had been immunized with two doses of inactivated vaccine, the booster administration of live attenuated vaccine was both effective and safe.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Sangue
/
Vacinas Atenuadas
/
Vacinas de Produtos Inativados
/
Imunização
/
Vacinas contra Encefalite Japonesa
/
Vírus da Encefalite Japonesa (Espécie)
/
Alergia e Imunologia
/
Anticorpos Antivirais
Limite:
Criança, pré-escolar
/
Humanos
Idioma:
Chinês
Revista:
Chinese Journal of Epidemiology
Ano de publicação:
2003
Tipo de documento:
Artigo
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