Study on the molecular biology of hemorrhagic fever virus in Xinjiang / 中华流行病学杂志
Chinese Journal of Epidemiology
; (12): 449-452, 2002.
Article
em Zh
| WPRIM
| ID: wpr-244246
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To explore the relationship between the structure and function at molecular level and the routes of transmission of Xinjiang hemorrhagic fever (XHF) virus.</p><p><b>METHODS</b>S genes of five XHF virus strains were cloned, sequenced and compared with that of other Crimean-Congo hemorrhagic fever virus strains.</p><p><b>RESULTS</b>It was found that S genes of the five viruses had 1,672 nuclei tides, while ORF of them including 1,449 nuclei tides and coded with a protein of 482 amino acid. The nucleotides homology of Chinese isolates (93.0%-99.5%) was obviously higher than that of any other S genes strains identified in other countries'. Phylogenetic tree showed that all Chinese isolates clustered into one branch and could be further divided into another three groups.</p><p><b>CONCLUSION</b>The sequential difference of S genes was not totally related to the host, areas and time of the viruses isolated.</p>
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Índice:
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Assunto principal:
Filogenia
/
Variação Genética
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Classificação
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Vírus da Febre Hemorrágica da Crimeia-Congo
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Genes Bacterianos
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Genética
Idioma:
Zh
Revista:
Chinese Journal of Epidemiology
Ano de publicação:
2002
Tipo de documento:
Article