Studies on the safety and immunogenicity of lyophilized live attenuated measles-mumps-rubella combined vaccine / 中华流行病学杂志
Chinese Journal of Epidemiology
;
(12): 435-437, 2002.
Artigo
em Chinês
| WPRIM
| ID: wpr-244250
ABSTRACT
<p><b>OBJECTIVE</b>To study the safety and immunogenicity of the measles-mumps-rubella combined vaccine (MMR) produced by Beijing Biological Product Institute.</p><p><b>METHODS</b>Children aged 10-12 years, 2-2.5 years and 8-12 months were selected to be vaccinated with Beijing MMR vaccine (test vaccine). Other groups of children with similar nature were vaccinated with measles vaccine, mumps vaccine and rubella vaccine while using imported MMR vaccine (control vaccine) as controls.</p><p><b>RESULTS</b>The safety of the Beijing MMR vaccine was confirmed after vaccinating 32 children above 2 years old. Among 104 children of 8-12 months were vaccinated with Beijing MMR vaccine, only 6.7% of the children had transient fever and 1.9% had signs of rashes but with no other signs observed. The positive seroconversion rates of measles, rubella and mumps anti-HI were 100%, 100% and 85.7% respectively. GMT also showed high lever.</p><p><b>CONCLUSION</b>The MMR vaccine (Beijing) had good safety and immunogenicity which might be used to be the bases enhance immunization of measles.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Sangue
/
Testes de Inibição da Hemaglutinação
/
Vacinas Atenuadas
/
Vacina contra Sarampo-Caxumba-Rubéola
/
Alergia e Imunologia
/
Liofilização
/
Anticorpos Antivirais
Limite:
Criança
/
Criança, pré-escolar
/
Humanos
Idioma:
Chinês
Revista:
Chinese Journal of Epidemiology
Ano de publicação:
2002
Tipo de documento:
Artigo
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