A case-control study on family history of Alzheimer's disease / 中华流行病学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To explore the relationship between Alzheimer's disease and its family history of the patients.</p><p><b>METHODS</b>Stratified analyses and logistic regression analysis were used to examine the association between Alzheimer's disease and its family history exposure in 127 cases and 254 matched controls from a population-based case-control study.</p><p><b>RESULTS</b>The risk of Alzheimer's disease was significantly higher in those who had at least one first-degree relative with dementia or major psychosis as compared to those who had no dementia or major relatives with psychosis (OR = 6.25; 8.33). Adjusted for age and level of education, family history of dementia was still associated with Alzheimer's disease positively (OR = 2.07).</p><p><b>CONCLUSION</b>This study provides evidence that familial aggregation of Alzheimer's disease might exist among people living Beijing.</p>