The effects of high frequency signal investigated in a neuron model / 生物医学工程学杂志
Journal of Biomedical Engineering
; (6): 1241-1245, 2009.
Article
em Zh
| WPRIM
| ID: wpr-244652
Biblioteca responsável:
WPRO
ABSTRACT
We have investigated the effects of high frequency (HF) signal on firing activity in a biologically realistic system--the noisy Hodgkin-Huxley (HH) neuron model via numerical simulations. The results show that when the HF amplitude to frequency ratio (AFR) increases, the firing rate is diminished and stochastic resonance disappears, even the HH neuron model is processing a stimulus of its most sensitive frequency. When the noise intensity is strong, the vibration resonance can be observed. Moreover, the fluctuation around the resting potential will be replaced by an oscillation of the same high frequency with the increasing AFR. The inhibition of the firing activity is consistent with the results of experiment in vivo that HF current can stop the transmission of action potential in peripheral nerve. This study is of functional significance to the biomedical research on the damages caused by electro-pollution in vivo and signal processing.
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Fisiologia
/
Simulação por Computador
/
Potenciais de Ação
/
Processos Estocásticos
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Artefatos
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Modelos Neurológicos
/
Neurônios
Limite:
Humans
Idioma:
Zh
Revista:
Journal of Biomedical Engineering
Ano de publicação:
2009
Tipo de documento:
Article