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Clinical comparison of the selective serotonin3 antagonists ramosetron and granisetron in treating acute chemotherapy-induced emesis, nausea and anorexia / 中国医学科学杂志(英文版)
Chinese Medical Sciences Journal ; (4): 168-172, 2002.
Artigo em Inglês | WPRIM | ID: wpr-244855
ABSTRACT
<p><b>OBJECTIVE</b>The efficacies of the selective 5-hydroxytryptamine3 (5-HT3) antagonists--ramosetron (0.3 mg) and granisetron (3 mg) in treating acute chemotherapy-induced digestive system dysunction were compared.</p><p><b>METHODS</b>A total of 111 patients were enrolled in a single-blind, randomised crossover study; with data from 98 were used to assess efficacy and data from 110 to assess the safety profile. Ramosetron or granisetron was given intraveneously 15 min befire chemotherpy.</p><p><b>RESULTS</b>The ability of ramosetron to prevent emesis, nausea and anorexia was similar to granisetron during the first 6 h following the administration of chemotherapy, ciplatin or doxorubicin. However, during the first 24 h after chemotherapy, significant differences between ramosetron and granisetron appeared emetic episode (P = 0.068), nausea (P = 0.006), and anorexia (P = 0.048) remained lower in ramosetron-treated patients. The safety profile of ramosetron was similar to that of granisetron and adverse events in both groups were generally mild and transient.</p><p><b>CONCLUSION</b>Ramosetron is more potent and longer-lasting than granisetron in preventing chemotherapy-induced digestive disturbances.</p>
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Antagonistas da Serotonina / Benzimidazóis / Vômito Precoce / Anorexia / Doxorrubicina / Método Simples-Cego / Cisplatino / Granisetron / Estudos Cross-Over / Usos Terapêuticos Tipo de estudo: Ensaio Clínico Controlado Limite: Adolescente / Adulto / Idoso / Feminino / Humanos / Masculino Idioma: Inglês Revista: Chinese Medical Sciences Journal Ano de publicação: 2002 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Antagonistas da Serotonina / Benzimidazóis / Vômito Precoce / Anorexia / Doxorrubicina / Método Simples-Cego / Cisplatino / Granisetron / Estudos Cross-Over / Usos Terapêuticos Tipo de estudo: Ensaio Clínico Controlado Limite: Adolescente / Adulto / Idoso / Feminino / Humanos / Masculino Idioma: Inglês Revista: Chinese Medical Sciences Journal Ano de publicação: 2002 Tipo de documento: Artigo