Design, synthesis and biological evaluation of fingolimod analogues containing diphenyl ether moiety / 药学学报
Acta Pharmaceutica Sinica
;
(12): 896-904, 2014.
Artigo
em Chinês
| WPRIM
| ID: wpr-244997
ABSTRACT
A novel series of fingolimod analogues containing diphenyl ether moiety were designed and synthesized based on the modification of immunosuppressive agent fingolimod used in the treatment of multiple sclerosis. Compounds were evaluated in vivo for lymphopenic activity and heart rate affection. Most compounds showed moderate lymphopenic activity. It is worth noting that compounds 6c, 6d and 14c-14e showed considerable immunosuppressive activities comparable to fingolimod. And compound 14e had no effect on heart rate.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Farmacologia
/
Éteres Fenílicos
/
Relação Estrutura-Atividade
/
Química
/
Cloridrato de Fingolimode
/
Frequência Cardíaca
/
Imunossupressores
/
Linfopenia
Limite:
Animais
Idioma:
Chinês
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2014
Tipo de documento:
Artigo
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