Rosiglitazone improves learning and memory impairment of 3 x Tg mice / 药学学报
Acta Pharmaceutica Sinica
; (12): 807-812, 2014.
Article
em Zh
| WPRIM
| ID: wpr-245011
Biblioteca responsável:
WPRO
ABSTRACT
This study is to investigate the protective effect of rosiglitazone (RSG) against learning and memory impairment of APP/PS1/tau transgenic mice. AD mice model was replicated by using 6-month APP/PS1/tau transgenic mice. The learning and memory ability of mice was evaluated by Morris water maze and Western blotting assays was applied to measure the phosphorylation and O-glycosylation of Tau and neurofilaments (NFs) protein. The results demonstrated that RSG could reverse the learning and memory deficits of 3 x Tg mice significantly. It was also found that RSG could suppress the hyperphosphorylation of Tau and NFs protein levels and increase the glycosylation expression of Tau and NFs proteins in 3 x Tg mice brain. Together, RSG ameliorates cognitive impairments of 3 x Tg mice via the alleviation of the hyperphosphorylated Tau and NFs proteins burden in the brain.
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Farmacologia
/
Fosforilação
/
Glicosilação
/
Encéfalo
/
Camundongos Transgênicos
/
Peptídeos beta-Amiloides
/
Proteínas de Neurofilamentos
/
Proteínas tau
/
Tiazolidinedionas
/
Modelos Animais de Doenças
Limite:
Animals
Idioma:
Zh
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2014
Tipo de documento:
Article