The impurity profiling of simvastatin and its tablets by UPLC-MS/MS / 药学学报
Acta Pharmaceutica Sinica
;
(12): 672-678, 2014.
Artigo
em Chinês
| WPRIM
| ID: wpr-245028
ABSTRACT
Investigation of simvastatin and its related substances was carried out using a reversed phase ultra performance liquid chromatography/tandem mass spectrometry method. The identification of impurities in simvastatin was performed with a triple-quadrupole mass spectrometer, with an electrospray ionization (ESI) source in the negative/positive ion mode. A total of 12 compounds were characterized in commercial samples, among which 2 impurities had never been reported. All the impurities were deduced based on the MS fragment pathways of simvastatin and the biosynthetic pathway of lovastatin. This work provides very useful information for quality control of simvastatin.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Controle de Qualidade
/
Comprimidos
/
Química
/
Contaminação de Medicamentos
/
Cromatografia Líquida de Alta Pressão
/
Sinvastatina
/
Espectrometria de Massas por Ionização por Electrospray
/
Espectrometria de Massas em Tandem
/
Cromatografia de Fase Reversa
/
Hipolipemiantes
Idioma:
Chinês
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2014
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS