Synthesis and in vitro cytotoxic activities of sorafenib derivatives / 药学学报
Acta Pharmaceutica Sinica
;
(12): 639-643, 2014.
Artigo
em Chinês
| WPRIM
| ID: wpr-245034
ABSTRACT
A series of novel sorafenib analogues were designed and synthesized. The cytotoxic activities of these compounds were tested in four tumor cell lines. Some of the compounds showed potent antiproliferative activity against the tested cell lines with IC50 = 4-20 micromol x L(-1). Some compounds demonstrated competitive antiproliferative activities to sorafenib against tested cancer cell lines. Among them, compound 7c demonstrated significant inhibitory activities on ACHN, HCT116 and MDA-MB-231 cell lines with IC50 values of 9.01, 4.97, 6.61 micromol x L(-1), respectively.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Compostos de Fenilureia
/
Relação Estrutura-Atividade
/
Estrutura Molecular
/
Química
/
Niacinamida
/
Concentração Inibidora 50
/
Linhagem Celular Tumoral
/
Proliferação de Células
/
Antineoplásicos
Limite:
Humanos
Idioma:
Chinês
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2014
Tipo de documento:
Artigo
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