Release kinetics of single pellets and the multi-pellet system of tamsulosin hydrochloride sustained release pellets / 药学学报
Acta Pharmaceutica Sinica
;
(12): 535-542, 2014.
Artigo
em Chinês
| WPRIM
| ID: wpr-245049
ABSTRACT
The release behavior of single pellet was investigated by LC/MS/MS method with tamsulosin hydrochloride (TSH) as the model drug of the research and then the pellets were divided into four groups according to the drug loading. Comparison of dissolution profiles of each group and capsule were performed using f1 and f2 factor methods to study the difference and similarity. The release profiles of single pellet, each group and capsule were analyzed using principle component analysis (PCA). The particle system was built through Matlab to get the target release profile. The result of this research demonstrated the release behavior of single pellet correlated well with the drug loading. While the dissolution profile of capsule as a reference, the similarity factor of dissolution profiles of the lower drug loading groups were 62.2, 67.1, 53.9, respectively and, 43.3 for highest drug loading group. The particle systems with different pellet distribution and same release profiles were built through release behavior of single pellet. It is of significance to investigate the release behavior of single pellets for studying the release regularity of multiple-unit drug delivery system.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Sulfonamidas
/
Cápsulas
/
Química
/
Química Farmacêutica
/
Cromatografia Líquida
/
Tecnologia Farmacêutica
/
Sistemas de Liberação de Medicamentos
/
Análise de Componente Principal
/
Preparações de Ação Retardada
/
Espectrometria de Massas em Tandem
Tipo de estudo:
Estudo prognóstico
Idioma:
Chinês
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2014
Tipo de documento:
Artigo
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