Identification of a new sildenafil analogue based on Q-TOF-MS / 药学学报
Acta Pharmaceutica Sinica
;
(12): 513-516, 2014.
Artigo
em Chinês
| WPRIM
| ID: wpr-245053
ABSTRACT
The drugs such as sildenafil adulterated in herbal products and dietary supplements may endanger human health. The number of the new modified derivatives is increasing recently. Based on Q-TOF-MS, a new sildenafil analogue was found. It was isolated and purified by preparative liquid chromatography. Its structure was determined by NMR, as 1-[4-propoxy-3-(6, 7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4, 3-d] pyrimidin-5-yl)phenylsulfonyl]-4-methylpiperazine. Compared with sildenafil, the ethoxy group of the benzene ring moiety was moved to the propoxy group, which had not been reported in China. The mass spectrometric behavior pattern of the structure type was summarized, which can greatly accelerate the structural analysis of novel analogues.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Piperazinas
/
Espectroscopia de Ressonância Magnética
/
Estrutura Molecular
/
Química
/
Contaminação de Medicamentos
/
Cromatografia Líquida de Alta Pressão
/
Suplementos Nutricionais
/
Espectrometria de Massas por Ionização por Electrospray
/
Citrato de Sildenafila
Tipo de estudo:
Estudo diagnóstico
Idioma:
Chinês
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2014
Tipo de documento:
Artigo
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