Research progresses of pharmacokinetics of polysaccharides / 药学学报
Acta Pharmaceutica Sinica
; (12): 443-449, 2014.
Article
em Zh
| WPRIM
| ID: wpr-245064
Biblioteca responsável:
WPRO
ABSTRACT
Pharmacokinetic analysis has attracted more and more attentions in the research field of bioactive natural product. However, there is limited study on the pharmacokinetics of polysaccharides. This paper focused on the research progresses of pharmacokinetics of polysaccharide, summarized the applications of chromatography, isotope labeling method, spectrophotometry, fluorospectrophotometry and biological assay in the analysis of polysaccharide pharmacokinetics, elucidated the behaviors of absorption, distribution, degradation and excretion of polysaccharide in experimental animals, and revealed the effects of physicochemical characteristic, administration dose and route on the pharmacokinetic properties of polysaccharide, which could be served as a reference for the related works.
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Polissacarídeos
/
Urina
/
Farmacocinética
/
Taxa de Depuração Metabólica
/
Distribuição Tecidual
/
Administração Oral
/
Injeções
/
Absorção Intestinal
/
Peso Molecular
Limite:
Animals
Idioma:
Zh
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2014
Tipo de documento:
Article