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Analysis of mutation sites of BRCA1 gene in Chinese patients with breast cancer / 中华医学遗传学杂志
Chinese Journal of Medical Genetics ; (6): 383-385, 2002.
Artigo em Chinês | WPRIM | ID: wpr-245297
ABSTRACT
<p><b>OBJECTIVE</b>To detect the mutation sites of exons 2, 20, 11A and 11B in Chinese patients with breast cancer.</p><p><b>METHODS</b>A total of 86 patients with breast cancer without blood relationship were randomly selected. Polymerase chain reaction (PCR) and double-strand DNA direct sequencing were applied.</p><p><b>RESULTS</b>No mutations, especially deletions were found in exons 2, 20 and 11 with carefully checking the sequencing results, although they were reported frequently in Europe populations with breast cancer. We found one polymorphism in exon 11, with high frequency, and in the test of chi-square, the frequencies of two alleles had no significant difference between the patients and controls.</p><p><b>CONCLUSION</b>The above results suggest this SNP may not be associated with the breast cancer in Chinese population, and indicates that the gene sequence of what we have studied doesn't account much for occurrence of the breast cancer in the population of China.</p>
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Polimorfismo Genético / Neoplasias da Mama / Éxons / Proteína BRCA1 / Povo Asiático / Frequência do Gene / Genética / Mutação Limite: Feminino / Humanos Idioma: Chinês Revista: Chinese Journal of Medical Genetics Ano de publicação: 2002 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Polimorfismo Genético / Neoplasias da Mama / Éxons / Proteína BRCA1 / Povo Asiático / Frequência do Gene / Genética / Mutação Limite: Feminino / Humanos Idioma: Chinês Revista: Chinese Journal of Medical Genetics Ano de publicação: 2002 Tipo de documento: Artigo