Linkage analysis of X-linked nuclear protein gene in Smith-Fineman-Myers syndrome / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 22-25, 2002.
Artigo
em Chinês
| WPRIM
| ID: wpr-245373
ABSTRACT
<p><b>OBJECTIVE</b>To determine the linkage between Smith-Fineman-Myers syndrome (SFMS) and X-linked nuclear protein(XNP) locus.</p><p><b>METHODS</b>Polymerase chain reaction and denaturing polyacrylamide gel electrophoresis were used to genotype two polymorphic short tandem repeats within XNP gene.</p><p><b>RESULTS</b>One of the two short tandem repeats was informative in SFMS family from Shandong, China. Recombination between SFMS locus and XNP gene was observed in the SFMS family.</p><p><b>CONCLUSION</b>XNP gene is not associated with the disease in the SFMS family from Shandong, China. SFMS exhibits locus heterogeneity at molecular level.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Linhagem
/
Fenótipo
/
Polimorfismo Genético
/
Recombinação Genética
/
Síndrome
/
Cromossomo X
/
Anormalidades Múltiplas
/
Proteínas Nucleares
/
DNA Helicases
/
Anormalidades Craniofaciais
Limite:
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Medical Genetics
Ano de publicação:
2002
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS