p53 gene codon 72 polymorphism and susceptibility to esophageal squamous cell carcinoma in a Chinese population / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 10-13, 2002.
Artigo
em Chinês
| WPRIM
| ID: wpr-245376
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the relationship between p53 codon 72 polymorphism and susceptibility to esophageal squamous cell carcinoma in China.</p><p><b>METHODS</b>The p53 genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism among 204 healthy controls and 91 patients with esophageal squamous cell carcinoma (ESCC).</p><p><b>RESULTS</b>There was no significant difference between patients and controls with respect to allele frequency for the p53 Pro allele (0.480 versus 0.588, P=0.11); however, the Pro/Pro genotype of p53 among cases (39.6%) was significantly (P<0.05) more frequent than that among controls (21.1%). Subjects homozygous for the p53 Pro allele had a more than 2-fold increased risk of developing ESCC (OR=2.18; 95%CI=1.10-4.35, adjusted for age, sex, and smoking), whereas the Arg/Pro genotype was not associated with elevated risk of the cancer (adjusted OR=0.84; 95%CI=0.42-1.68). No interaction between smoking and Pro/Pro genotype was observed for risk of ESCC.</p><p><b>CONCLUSION</b>The p53 codon 72 polymorphism may play a role in susceptibility to esophageal carcinogenesis.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Arginina
/
Polimorfismo Genético
/
Códon
/
Neoplasias Esofágicas
/
Prolina
/
Carcinoma de Células Escamosas
/
Intervalos de Confiança
/
Razão de Chances
/
Proteína Supressora de Tumor p53
/
Predisposição Genética para Doença
Tipo de estudo:
Estudo de etiologia
Limite:
Humanos
Idioma:
Chinês
Revista:
Chinese Journal of Medical Genetics
Ano de publicação:
2002
Tipo de documento:
Artigo
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