Nephrotic syndrome complicated with intracranial venous thrombosis treated with urokinase: report of 5 cases / 中华儿科杂志
Chinese Journal of Pediatrics
; (12): 338-341, 2010.
Article
em Zh
| WPRIM
| ID: wpr-245401
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To explore the effect of urokinase and low molecular weight heparin in children with nephrotic syndrome complicated with intracranial venous thrombosis.</p><p><b>METHODS</b>Urokinase and low molecular weight heparin were administered to the 5 patients intravenously. The initial dose of urokinase was 2000 - 4000 U/(kg.d), the initial pulse dose was 20 000 - 40 000 U given within 15 - 30 minutes, and the left was infused by using a pump, from the second day 2000 U/(kg.d) urokinase was infused daily for 3 to 7 days. During the treatment thrombin time (TT), activated partial thromboplastin time (APTT) were tested 3 times every week, with particular attention to bleeding. Low molecular weight heparin 100 - 120 AXaIU/kg, 1 or 2 times per day was hypodermally injected for a course of two weeks. Anti-platelet drugs: long-term oral administration of dipyridamole 3 - 5 mg/(kg.d) was applied 2 - 3 times every day for 3 months.</p><p><b>RESULTS</b>The clinical symptoms disappeared after one month of the combined therapy of urokinase, low molecular weight heparin and dipyridamole in 5 cases of nephrotic syndrome complicated with intracranial venous thrombosis in children, the plasma viscosity returned to normal in 1 month, activated partial thromboplastin time, prothrombin time, fibrinogen degradation products returned to normal in 1 to 2 months, venous thrombosis disappeared after 1 to 3 months in head CT or MRI examination, showing the cerebral venous sinus thrombosis complete recanalization without relapse cases in follow-up.</p><p><b>CONCLUSION</b>The early application of urokinase and low molecular heparin and anti-platelet coagulation drugs was effective. The early diagnosis, treatment and prevention of intracranial vein thrombosis in patients with nephrotic syndrome is important.</p>
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Prognóstico
/
Trombose dos Seios Intracranianos
/
Ativador de Plasminogênio Tipo Uroquinase
/
Resultado do Tratamento
/
Usos Terapêuticos
/
Diagnóstico Precoce
/
Fibrinolíticos
/
Síndrome Nefrótica
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
/
Screening_studies
Limite:
Adolescent
/
Child
/
Humans
/
Male
Idioma:
Zh
Revista:
Chinese Journal of Pediatrics
Ano de publicação:
2010
Tipo de documento:
Article