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Inhibition of hepatitis B virus replication and expression by RNA interference in vivo / 中华肝脏病杂志
Chinese Journal of Hepatology ; (12): 15-18, 2006.
Artigo em Chinês | WPRIM | ID: wpr-245764
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the inhibitory effect of small interfering RNA (siRNA) targeting HBV C gene region on hepatitis B virus (HBV) in vivo.</p><p><b>METHODS</b>An animal model of HBV infection was developed hydrodynamically, and pcDNA3.1-HBV and siRNA were together injected into the tail vein of the BALB/c mice. HBsAg was analyzed by time-resolved immunofluorometric assay, HBV DNA was analyzed by fluorogenic quantitative PCR (FQ-PCR), HBV C-mRNA was detected by semi-quantitative RT-PCR, and viral specific proteins (HBsAg and HBcAg) in the mice livers were assayed using immunohistochemical staining.</p><p><b>RESULTS</b>In the mice, the siRNA effectively inhibited HBV replication and expression compared with the controls. The inhibitive effect of siRNA on HBV lasted at least 3 days.</p><p><b>CONCLUSION</b>These results demonstrate that RNAi can substantially inhibit HBV replication and expression in vivo.</p>
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Fisiologia / Terapêutica / Replicação Viral / Distribuição Aleatória / Vírus da Hepatite B / Complexo de Inativação Induzido por RNA / RNA Interferente Pequeno / Genética / Hepatite B / Camundongos Endogâmicos BALB C Limite: Animais Idioma: Chinês Revista: Chinese Journal of Hepatology Ano de publicação: 2006 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Fisiologia / Terapêutica / Replicação Viral / Distribuição Aleatória / Vírus da Hepatite B / Complexo de Inativação Induzido por RNA / RNA Interferente Pequeno / Genética / Hepatite B / Camundongos Endogâmicos BALB C Limite: Animais Idioma: Chinês Revista: Chinese Journal of Hepatology Ano de publicação: 2006 Tipo de documento: Artigo