Expression of transgelin-2 and clinical significance in colorectal cancer / 中华外科杂志
Chinese Journal of Surgery
;
(12): 551-554, 2012.
Artigo
em Chinês
| WPRIM
| ID: wpr-245830
ABSTRACT
<p><b>OBJECTIVES</b>To investigate the relationship between the expression of transgelin-2 and the clinicopathological factors of colorectal carcinoma and evaluate the value of transgelin-2 in prognostic assessment of the colorectal cancer patients.</p><p><b>METHODS</b>Using tissue microarray and immunohistochemical methods, we examined transgelin-2 of 120 colorectal cancer patients received surgical treatment from September 2002 to April 2004, including 74 male and 46 female, age from 26 to 89 years. Analyzed the relationship between transgelin-2 and both the clinicopathological features and prognosis of the colorectal cancer by using χ² test and Kaplan-Meier survival analysis. Cox proportion hazard regression analysis was used to study the independent prognostic factors.</p><p><b>RESULTS</b>The positive rate of transgelin-2 expression was 69.2% in colorectal carcinoma. The transgelin-2 expression correlated with differentiation degree (χ² = 5.420), lymph nodes metastasis (χ² = 45.577), distant metastasis (χ² = 12.009), and TNM staging (χ² = 47.577). The survival time was (39 ± 5) months in patients with positive expression of the transgelin-2, while (59 ± 3) months in patients with negative expression. The patient's survival time was statistically correlated with the transgelin-2 expression (P = 0.003). Distant metastasis (RR = 8.318, 95%CI 4.119 - 16.790), lymph nodes metastasis (RR = 2.794, 95%CI 1.246 - 6.263) and transgelin-2 expression (RR = 1.834, 95%CI 1.118- 2.973) were independent prognostic factors in patients with colorectal cancer (P < 0.05).</p><p><b>CONCLUSIONS</b>The expression of transgelin-2 is correlated with clinicopathological features and prognosis in colorectal cancer, may be the potential marker of metastasis and the prognosis of colorectal cancer patients.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Prognóstico
/
Neoplasias Colorretais
/
Análise de Regressão
/
Estimativa de Kaplan-Meier
/
Metabolismo
/
Proteínas dos Microfilamentos
/
Proteínas Musculares
Tipo de estudo:
Estudo diagnóstico
/
Estudo prognóstico
Limite:
Adulto
/
Idoso
/
Aged80
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Surgery
Ano de publicação:
2012
Tipo de documento:
Artigo
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