Efficacy and Tolerability of Rufinamide for Intractable Generalized Epilepsies / 대한소아신경학회지
Journal of the Korean Child Neurology Society
;
(4): 164-169, 2012.
Artigo
em Coreano
| WPRIM
| ID: wpr-24591
ABSTRACT
PURPOSE:
The purpose of the study was to evaluate the efficacy and safety of rufinamide for intractable generalized epilepsies.METHODS:
Eighteen patients with intractable generalized epilepsies were included in the study. Their medical records were retrospectively reviewed. Rufinamide was administered as an add-on treatment for intractable epilepsies. The initial administered dose was 10 mg/kg/day, which was subsequently titrated up to 30-50 mg/kg/day. The effectiveness was assessed by comparing the frequency of seizures after the treatment. The difference in number of seizures during 4 weeks was compared before and after reaching the final dose.RESULTS:
The study population consisted of 13 males and 5 females (mean age 13.6+/-6.2 years, range 3.3-29.2 years). The responder rate (> or =50% in seizure frequency) was 39% and the seizure free rate was 11%. Retention rate was 44% and the reasons for withdrawal was adverse events (6/18 patients, 33%), aggravation of seizures (4/18 patients, 22%), and ineffectiveness (2/18 patients, 11%). Adverse events included hyperactivity, somnolence, ataxia and polyhidrosis. Adverse events and seizure aggravation occurred even at the starting dose of rufinamide treatment.CONCLUSION:
Rufinamide can be used as an efficacious and safe adjunctive anticonvulsant for patients with intractable generalized epilepsy.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Retenção Psicológica
/
Ataxia
/
Convulsões
/
Triazóis
/
Prontuários Médicos
/
Estudos Retrospectivos
/
Epilepsia Generalizada
/
Epilepsia
Tipo de estudo:
Estudo observacional
Limite:
Feminino
/
Humanos
/
Masculino
Idioma:
Coreano
Revista:
Journal of the Korean Child Neurology Society
Ano de publicação:
2012
Tipo de documento:
Artigo
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