Preparation and evaluation of sustained-release microsphere of Sanguis Draconis in vitro / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 388-390, 2007.
Artigo
em Chinês
| WPRIM
| ID: wpr-245971
ABSTRACT
<p><b>OBJECTIVE</b>To prepare sustained-release microsphere containing extract of Sanguis Draconis and to measure its dissolution in vitro.</p><p><b>METHOD</b>Sustained-release microsphere was prepared with polylactic acid (PLA) as carriers using the oil-in-water (O/W) emulsion solvent evaporation method. The powder particle's characteristics of sustainded-release microsphere were evaluated comprehensively, and its dissolution characteristics in vitro were studied.</p><p><b>RESULT</b>The microsphere was round and its surface was smooth, drug-loading rate was 21.97% and the entrapment rate was 55.76%, the accumulative release percentage was 76. 71% in 16 hours.</p><p><b>CONCLUSION</b>The sustained release effect of Sanguis Draconis microspheres was formed with potentially wide applications.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Tamanho da Partícula
/
Plantas Medicinais
/
Poliésteres
/
Polímeros
/
Resinas Vegetais
/
Medicamentos de Ervas Chinesas
/
Química
/
Reprodutibilidade dos Testes
/
Tecnologia Farmacêutica
/
Ácido Láctico
Idioma:
Chinês
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2007
Tipo de documento:
Artigo
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