Blood lipid-regulation of stilbene glycoside from polygonum multiflorum / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 323-326, 2007.
Artigo
em Chinês
| WPRIM
| ID: wpr-245981
ABSTRACT
<p><b>OBJECTIVE</b>To study lipid-regulating action of 2, 3, 5, 4'-tetrahydroxy stilbene-2-O-beta-D-glucopyranoside (TSG) from Polygonum multiflorum on experimental model hyperlipidemic rats.</p><p><b>METHOD</b>TSG 90 and 180 mg x kg(-10 x d(-1), atorvastatin mg kg(-1) x d(-1) and saline 2 mL x d(-1) were administered to hyperlipidemic rats. Groups of rats were determined and compared with those of saline group. The LDLR and HMGR mRNA expression were also detected.</p><p><b>RESULT</b>TSG significantly reduced serum TC and LDL-C level and atherosclerosis index, increased the expression of LDLR in the liver cells.</p><p><b>CONCLUSION</b>TSG, which shows effects and mechanism in part like atorcastatin, is a major constituent with blood-lipid regulating effect of P. multiflorum and can be explored as a potent medication for hyperlipidemia. Effects on LDL-C and AI, as well as on gene expression of TSG were first reported.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Plantas Medicinais
/
Pirróis
/
Estilbenos
/
Triglicerídeos
/
Sangue
/
RNA Mensageiro
/
Receptores de LDL
/
Distribuição Aleatória
/
Química
Limite:
Animais
Idioma:
Chinês
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2007
Tipo de documento:
Artigo
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