Fragmentation pathways of five furocoumarine using line ion trap with orbitrapmass spectrometry / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 1334-1341, 2015.
Artigo
em Chinês
| WPRIM
| ID: wpr-246099
ABSTRACT
<p><b>OBJECTIVE</b>The multiple levels fragmentations of five furocoumarine (psoralen, xanthotoxin, bergapten, oxypeucedanin, and byakangelicol) in Angelica dahurica have been demonstrated using LTQ-Orbitrap mass spectrometry with high resolution and high mass accuracy to discover the possible,fragmentation regularity.</p><p><b>METHOD</b>Duringcollsion-induced dissociation (CID), the MS(n) data of the five compoundswhich were gained in the positive ion mode at 35ev collision energy by direct injection syrings method were analyzed using Xcalibar 2.0 Software to infer the formula of these fragmentations.</p><p><b>RESULT</b>The results indicated that the five compounds have similar fragmentation process with CO meutral lost at C5,C8-subsituents and furan ring, meanwhile the meutralloss of CO2 occurred easily at lactone group.</p><p><b>CONCLUSION</b>This method is helpful in identifying the structures of other furocoumarinein Angelica dahuricaand their metabolites in vivo.</p>
Texto completo:
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Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Espectrometria de Massas
/
Medicamentos de Ervas Chinesas
/
Estrutura Molecular
/
Química
/
Cumarínicos
/
Angelica
/
Fenômenos Químicos
/
Métodos
Idioma:
Chinês
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2015
Tipo de documento:
Artigo
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