Chemical constituents from culture of Streptomyces sp. CPCC 202950 / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 1320-1324, 2015.
Article
em Zh
| WPRIM
| ID: wpr-246102
Biblioteca responsável:
WPRO
ABSTRACT
Eleven compounds were isolated from the culture of Streptomyces sp. CPCC 202950 by a combination of various chromatographic techniques including column chromatography over macroporous resin HP-20, MCI, and reversed-phase HPLC. Their structures were identified as 1H-pyrrole-2-carboxamide(1),5'-deoxy-5'-methylthioinosine(2), vanillamide(3), trans-3-methylthioacrylamide(4), 1,2,3,4-Tetraydro-1H-pyrido[3,4-b]indole-3-carboxylic acid(5), cyclo(L-pro-L-tyr) (6), N-[2-(4-hydroxyphenyl)]ethylacetamide(7), benzamide (8), cyclo ('L-leucyl-trans-4-hydroxy-L-proline)(9), cyclo-(Phe-Gly) (10), and tryptophan (11). Among them, compounds 1 and 2 were new natural products. In the preliminary assays, none of the compounds exhibited obvious inhibition of HIV-1 protease activity (IC50 > 10 micromol x L(-1)).
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Índice:
WPRIM
Assunto principal:
Streptomyces
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Estrutura Molecular
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Química
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Protease de HIV
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Inibidores da Protease de HIV
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Meios de Cultura
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Espectrometria de Massas por Ionização por Electrospray
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Metabolismo
Idioma:
Zh
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2015
Tipo de documento:
Article