Effects of Beta-Blocker on Cardiorespiratory Fitness Factors and Blood Lipid of Patients with Acute Coronary Syndrome / 대한스포츠의학회지

ABSTRACT

The purpose of this study is to investigate effects of beta-blocker prescribed at the beginning of cardiac rehabilitation exercise for patients with acute coronary syndrome (ACS) on cardiorespiratory fitness factors and blood lipid at the 6th and the 14th week. The subjects of this study were patients (beta blocker group: n=20, non-beta blocker group: n=22) who underwent internal procedure because of ACS. The patients were conducted of exercise stress test and blood lipid before cardiac rehabilitation (the first period), were additionally prescribed of beta-blocker by cardiologist at the first week, and were conducted of exercise stress test and blood lipid at the 6th (the second period) and the 14th (the third period) week. Based on the results of this study, rest heart rate, maximal rate pressure product, sub-maximal rate pressure product, time and rate of perceived exertion showed no significant differences between groups, but peakVO2 showed interaction effect between treatment and period. All the items of blood lipid showed no differences between the groups. Conclusively, the group of beta-blocker administration showed negative effect on increase in peakVO2 at the 6th week but had positive effect at the 14th week. Meanwhile, beta-blocker did not affect blood lipid. Therefore, when patients with cardiovascular disease were additionally administered of beta-blocker at earlier period of cardiac rehabilitation, it may be needed of training time of at least six weeks to increase peakVO2.