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Study on EB virus infection, LMP1 and Bcl-2 expression in lung cancer patients / 中华实验和临床病毒学杂志
Chinese Journal of Experimental and Clinical Virology ; (6): 277-279, 2011.
Artigo em Chinês | WPRIM | ID: wpr-246266
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the Epstein-Barr virus (EBV) infection, the expression of EBV latent membrane protein 1 ( LMPl) and oncogene bcl-2 in lung cancer patients.</p><p><b>METHODS</b>EBERI in 108 cases of lung cancer were detected with in situ hybridization. EBV positive and negative lung cancer tissues were analysed for the expression of LMP1 and Bcl-2 by immnohistochemistry. The average area (AA) and integral optical density (IA) of each sample was measured with the digital medical image analyzing system.</p><p><b>RESULTS</b>In 108 cases of lung cancer, 36 cases were EBER1 positive and 7 cases were LMP1 positive. The expression of Bcl-2 was higher in EBV positive lung cancer tissues than that in EBV negative. The AA value was 58014.23 +/- 6918.45 and 38156.22 +/- 4096.79, while the IA value was 11.00 +/- 1.48 and 8.03 +/- 0.78 respectively. No statistic difference was fund in the expression of Bcl-2 betwen LMP1 positive and negative lung cancer tisssues.</p><p><b>CONCLUSION</b>EBV infection in lung cancer increased the expression of bcl-2, which may play a role in the occurrence or development of lung cancer. The increased expression of Bcl-2 may not be induced by LMP1. The exact mechanism need further study.</p>
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Patologia / Fisiologia / Virologia / Regulação Viral da Expressão Gênica / Proteínas da Matriz Viral / Herpesvirus Humano 4 / Proteínas Proto-Oncogênicas c-bcl-2 / Infecções por Vírus Epstein-Barr / Genética / Neoplasias Pulmonares Limite: Adulto / Idoso / Humanos / Masculino Idioma: Chinês Revista: Chinese Journal of Experimental and Clinical Virology Ano de publicação: 2011 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Patologia / Fisiologia / Virologia / Regulação Viral da Expressão Gênica / Proteínas da Matriz Viral / Herpesvirus Humano 4 / Proteínas Proto-Oncogênicas c-bcl-2 / Infecções por Vírus Epstein-Barr / Genética / Neoplasias Pulmonares Limite: Adulto / Idoso / Humanos / Masculino Idioma: Chinês Revista: Chinese Journal of Experimental and Clinical Virology Ano de publicação: 2011 Tipo de documento: Artigo