A molecular epidemiological study on the human immunodeficiency virus infection in Jiangsu province / 中华流行病学杂志
Chinese Journal of Epidemiology
; (12): 976-979, 2003.
Article
em Zh
| WPRIM
| ID: wpr-246421
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To identify subtypes of human immunodeficiency virus 1 (HIV-1) strains and their distribution, infection sources, and the trends of HIV infection in Jiangsu province.</p><p><b>METHODS</b>Anticongulated bloods from 46 infected persons were collected to separate previrus DNA. HIV-1 env genes were then amplified by nested-PCR and sequenced for their C2-V3 region so as to identify subtypes. The analysis of consensus sequence, genetic distance and phylogenetic tree were conducted with GCG software.</p><p><b>RESULTS</b>By the end of 2001, there had been six subtypes of HIV-1 strains identified in Jiangsu province: A, B, B', C, D and E. The predominant subtypes were C (accounting for 40.48%) and B' (accounting for 38.10%). Subtype C accounted for 86.67% among injecting DUs while subtype B' accounted for 91.67% among commercial blood donors and receivers.</p><p><b>CONCLUSION</b>Subtype B'among commercial blood donors was brought to Jiangsu from neighboring provinces. The outbreak of HIV-1 infection among local DUs was caused by subtype C from Xinjiang province. Findings from HIV/AIDS molecular epidemiologic study suggest that it is challenging for Jiangsu to treat patients, apply vaccine, prevent and control AIDS in the future.</p>
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Índice:
WPRIM
Assunto principal:
Sangue
/
Genes env
/
Infecções por HIV
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Soroprevalência de HIV
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China
/
Reação em Cadeia da Polimerase
/
Epidemiologia
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HIV-1
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Classificação
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Análise de Sequência de DNA
Limite:
Humans
País/Região como assunto:
Asia
Idioma:
Zh
Revista:
Chinese Journal of Epidemiology
Ano de publicação:
2003
Tipo de documento:
Article