Research progress of abnormal phosphorylation of microtubule-associated tau protein and of the targeted inhibition of the phosphorylation / 生物医学工程学杂志
Journal of Biomedical Engineering
;
(6): 788-792, 2012.
Artigo
em Chinês
| WPRIM
| ID: wpr-246558
ABSTRACT
Progressive dementia is described as the first and most prominent symptom of Alzheimer's disease (AD), and hyperphosphorylation of microtubule associated Tau protein (MAPT) plays a key role in neurodegeneration and neuronal dysfunction in AD and other neurodegenerative diseases. This paper reviews several protein kinases and phosphatases which can phosphorylate/dephosphorylate Tau protein, and evaluates a therapeutic strategy based on targeted inhibition of Tau kinases and activation of Tau phosphatases.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fosforilação
/
Fisiologia
/
Proteínas Quinases
/
Química
/
Proteínas tau
/
Monoéster Fosfórico Hidrolases
/
Doenças Neurodegenerativas
/
Quinase 3 da Glicogênio Sintase
/
Doença de Alzheimer
/
Metabolismo
Limite:
Humanos
Idioma:
Chinês
Revista:
Journal of Biomedical Engineering
Ano de publicação:
2012
Tipo de documento:
Artigo
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