The expression of interleukin-10 mRNA in gingival lesion of different clinical states in patients with adult periodontitis / 华西口腔医学杂志
West China Journal of Stomatology
;
(6): 417-419, 2010.
Artigo
em Chinês
| WPRIM
| ID: wpr-246570
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expression of interleukin-10 (IL-10) mRNA in gingival tissue of active and stable stage in patients with adult periodontitis.</p><p><b>METHODS</b>12 patients with acute abscesses of the periodontium, 12 patients after periodontal initial treatment and 6 periodontal healthy patients having extraction of impacted wisdom tooth were randomly divided into group A (active stage group), group B (stable stage group) and the control group. Biopsies of gingival tissues were collected from every subject of three groups. Technique of in situ hybridization was applied to observe the expression of IL-10 mRNA in the biopsies from three groups semi-quantitatively.</p><p><b>RESULTS</b>IL-10 mRNA was positively expressed in lymphocytes, macrophages and fibroblasts. The quantity of IL-10 mRNA of group A was the lowest in the three groups and was significantly lower than that of control group and group B respectively (P < 0.01). The quantity of IL-10 mRNA of group B was the highest in the three groups and was significantly higher compared with the control group and group A (P < 0.01).</p><p><b>CONCLUSION</b>The quantities of IL-10 mRNA expression are closely related with various clinical states of periodontitis.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
RNA Mensageiro
/
Estudos de Casos e Controles
/
Interleucina-10
/
Periodontite Crônica
/
Gengiva
/
Metabolismo
Tipo de estudo:
Estudo observacional
Limite:
Humanos
Idioma:
Chinês
Revista:
West China Journal of Stomatology
Ano de publicação:
2010
Tipo de documento:
Artigo
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