Immunohistochemical presentation of fibromodulin during wound healing of periodontal cells / 华西口腔医学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To investigate immunohistochemical presentation of fibromodulin in vitro during wound healing of three types of periodontal cells and discuss the role of fibromodulin.</p><p><b>METHODS</b>Cultured periodontal cells were wounded and followed by observation up to 7 days. The immunohistochemical expression of fibromodulin in periodontal cells was observed.</p><p><b>RESULTS</b>Immunohistochemical localization of fibromodulin during cellular wound healing showed that newly migrating periodontal cells toward the wound area were expressed strongly for fibromodulin at day 1 after wounding; thereafter, fibromodulin expression was noted stronger in newly migrating periodontal cells localized in the central part of the wound area than those around the wound area.</p><p><b>CONCLUSION</b>These data suggest that fibromodulin may be involved in the early events of wound healing for periodontal cells.</p>