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Differentiation of K562 Cells Induced by Pulsatilla Saponin A into Erythroid Lineage / 中国实验血液学杂志
Journal of Experimental Hematology ; (6): 975-979, 2016.
Artigo em Chinês | WPRIM | ID: wpr-246832
ABSTRACT
<p><b>OBJECTIVE</b>To explore the differentiation-inducing potentiality of Pulsatilla saponin A on K562 cells.</p><p><b>METHODS</b>Pulsatilla saponin A of different concentrations was used to treat K562 cells; the benzidine staining and the hemoglobinometry were applied to measure the change of hemoglobin content; the flow cytometry (FCM) was used to detect the expression of CD71 and GPA on K562 cells.</p><p><b>RESULTS</b>K562 cells treated with 4 µg/ml pulsatilla saponin A differentiated into the erythroid lineage. With the treatment of pulsatilla saponin A, the hemoglobin content in K562 cells increased significantly; CD71 and GPA expression on the K562 cell surface were up-regulated.</p><p><b>CONCLUSION</b>Pulsatilla saponin A can induce K562 cells to differentiate into erythroid lineage.</p>
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Saponinas / Diferenciação Celular / Linhagem da Célula / Células K562 / Células Eritroides / Antineoplásicos Limite: Humanos Idioma: Chinês Revista: Journal of Experimental Hematology Ano de publicação: 2016 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Saponinas / Diferenciação Celular / Linhagem da Célula / Células K562 / Células Eritroides / Antineoplásicos Limite: Humanos Idioma: Chinês Revista: Journal of Experimental Hematology Ano de publicação: 2016 Tipo de documento: Artigo