Preliminary clinical study on the treatment of severe infantile hemangioma with high-dose propranolol in China / 中华整形外科杂志
Chinese Journal of Plastic Surgery
;
(6): 166-169, 2011.
Artigo
em Chinês
| WPRIM
| ID: wpr-246964
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the clinical results of the treatment of severe infantile hemangioma with high-dose propranolol in Chinese.</p><p><b>METHODS</b>56 cases with severe infantile hemangioma were treated with propranolol. Clinical evaluation, electrocardiography, and experimental examination of liver function and heart function were performed before treatment. The daily dose of propranolol was increased from 1 mg/kg at the first day to 1.5 mg/kg at the second day, and to 2 mg/kg at the third day. The propranolol was given twice a day. The treatment was lasted for six months. The patients were visited every month.</p><p><b>RESULTS</b>The lesion color was changed after 2-4 days of treatment in all the cases. All the lesions were dramatically improved after one month of treatment. The ulceration were healed, except one case. Until now, complete regression was achieved in 10 cases and marked improvement in 46 cases. Side effects were happened in 3 cases, including one case of abnormal liver function, one case of CK-MB increase and one case of continuous increase of CK-MB, LDH, ALT, GGT.</p><p><b>CONCLUSIONS</b>High-dose Propranolol is very effective in the treatment of infantile hemangioma with minor side effects and short disease period. It might he used as the first-line treatment for infantile hemangioma.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Propranolol
/
China
/
Resultado do Tratamento
/
Usos Terapêuticos
/
Tratamento Farmacológico
/
Hemangioma
Limite:
Feminino
/
Humanos
/
Lactente
/
Masculino
País/Região como assunto:
Ásia
Idioma:
Chinês
Revista:
Chinese Journal of Plastic Surgery
Ano de publicação:
2011
Tipo de documento:
Artigo
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