Subacute effect of decabromodiphenyl ethane on hepatotoxicity and hepatic enzyme activity in rats / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences
;
(12): 122-125, 2014.
Artigo
em Inglês
| WPRIM
| ID: wpr-247075
ABSTRACT
Information regarding decabromodiphenyl ethane (DBDPE) effects on hepatotoxicity and metabolism is limited. In the present study, Wistar rats were given oral DBDPE at different doses. DBDPE induced oxidative stress, elevated blood glucose levels, increased CYP2B2 mRNA, CYP2B1/2 protein, 7-pentoxyresorufin O-depentylase (PROD) activity, and induced CYP3A2 mRNA, CYP3A2 protein, and luciferin benzylether debenzylase (LBD) activity. UDPGT activity increased with its increasing exposure levels, suggesting that oral DBDPE exposure induces drug-metabolizing enzymes in rats via the CAR/PXR signaling pathway. The induction of CYPs and co-regulated enzymes of phase II biotransformation may affect the homeostasis of endogenous substrates, including thyroid hormones, which may, in turn, alter glucose metabolism.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Bromobenzenos
/
Distribuição Aleatória
/
Ratos Wistar
/
Testes de Toxicidade
/
Toxicidade
/
Doença Hepática Induzida por Substâncias e Drogas
/
Retardadores de Chama
/
Fígado
/
Metabolismo
Limite:
Animais
Idioma:
Inglês
Revista:
Biomedical and Environmental Sciences
Ano de publicação:
2014
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS