Research progress on MKP-1 in tumor drug resistance / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
;
(6): 111-116, 2012.
Artigo
em Chinês
| WPRIM
| ID: wpr-247174
ABSTRACT
The main obstacle for chemotherapy is tumor drug resistance. Studying the mechanisms of drug resistance and reversing drug resistance is the key to improve the effectiveness of chemotherapy. It has been reported that MKP-1 plays an important role in tumor drug resistance. MKP-1, as a negative regulator of MAPKs, is involved in the MAPKs mediated drug resistance and is regulated by ERK and p38 signaling pathways.However, the relationship between MKP-1 and other drug resistance-related signaling pathways is not clear and requires further investigation.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fisiologia
/
Transdução de Sinais
/
Resistencia a Medicamentos Antineoplásicos
/
Fosfatase 1 de Especificidade Dupla
/
Metabolismo
Limite:
Humanos
Idioma:
Chinês
Revista:
Journal of Zhejiang University. Medical sciences
Ano de publicação:
2012
Tipo de documento:
Artigo
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