Association of Helicobacter pylori infection and serum homocysteine level in patients with cerebral infarction / 浙江大学学报·医学版

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the association of Helicobacter pylori infection and serum homocysteine(Hcy) levels with acute cerebral infarction.</p><p><b>METHODS</b>Serum Hp-IgG, Hp-CagA-IgG and Hcy were detected by biological micro-array analysis system in 85 patients with acute cerebral infarction and 40 healthy subjects (control group).</p><p><b>RESULTS</b>The positive rates of Hp-IgG and Hp-CagA-IgG significantly increased in cerebral infarction group compared with controls (P<0.05). There were significant differences in serum Hcy level between Hp-CagA-IgG positive and negative patients (P<0.05), but not between Hp-IgG positive and negative patients (P>0.05).</p><p><b>CONCLUSION</b>CagA-positive Hp infection may increase the risk of cerebral infarction, which might be associated with the increased serum homocysteine level.</p>