389A/G polymorphism of the human beta1-adrenergic receptor in patients with acute myocardial infarction / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 422-424, 2007.
Artigo
em Chinês
| WPRIM
| ID: wpr-247303
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the relation between the 389A/G polymorphism in the human beta 1-adrenergic receptor and acute myocardial infarction (AMI).</p><p><b>METHODS</b>Polymerase chain reaction amplification and restriction fragment length polymorphism analysis were used to detect the genotypes of 150 patients with AMI and 150 age- and sex- matched control subjects, and relative clinical data were obtained. A case-control study and multiple Logistic regression analysis were performed to assess the association between 389A/G polymorphism and AMI.</p><p><b>RESULTS</b>The distributions of the genotypes and allele frequencies were significantly different between two groups (P< 0.01). The prevalence of the A allele was significantly higher in patients with AMI than in control subjects. In the multivariate regression analysis, the 389A/G polymorphism (OR 2.88, 95%CI 1.70-4.88, P< 0.01), smoking(OR 2.72, 95%CI 1.52-4.88, P< 0.01), hyperlipidemia (OR 2.85, 95%CI 1.68-4.86, P< 0.01), diabetes mellitus(OR 2.38, 95%CI 1.27-4.47, P< 0.01) and hypertension (OR 2.00, 95%CI 1.62-3.45, P< 0.05) were independent risk factors of AMI.</p><p><b>CONCLUSION</b>The 389A/G polymorphism in the human beta 1-adrenergic receptor is associated with AMI and is an independent risk factor of AMI.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fumar
/
Estudos de Casos e Controles
/
Modelos Logísticos
/
Reação em Cadeia da Polimerase
/
Análise Multivariada
/
Fatores de Risco
/
Receptores Adrenérgicos beta 1
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Predisposição Genética para Doença
/
Polimorfismo de Nucleotídeo Único
/
Frequência do Gene
Tipo de estudo:
Estudo de etiologia
/
Estudo observacional
/
Estudo prognóstico
/
Fatores de risco
Limite:
Adulto
/
Idoso
/
Aged80
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Medical Genetics
Ano de publicação:
2007
Tipo de documento:
Artigo
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