Association mapping of schizophrenia loci on chromosome 1 by use of pooled DNA genomic screening in eastern Shandong peninsula / 中华医学遗传学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To find out association mapping of loci related to schizophrenia on chromosome 1 with microsatellite markers in DNA pooling samples from schizophrenic cases and normal controls in Shandong peninsula.</p><p><b>METHODS</b>A total of 31 microsatellite markers on chromosome 1 spaced at approximately 10 cM were scanned to two separated DNA pooling samples consisting of 119 schizophrenic cases and 119 normal controls respectively. Statistic analysis was performed by Chi-square test method to compare the difference between the ratio of each allele between the two pooling samples.</p><p><b>RESULTS</b>Significant statistic difference was found at D1S2878 between cases and controls, and P< 0.01 at this loci.</p><p><b>CONCLUSION</b>D1S2878 locus on chromosome 1 associates with schizophrenia in Shandong peninsula. Fine mapping and searching for candidate genes are warranted in this region.</p>