Study on the vertical transmission of Y chromosome microdeletions from father to son / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
; (6): 203-205, 2007.
Article
em Zh
| WPRIM
| ID: wpr-247352
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To analyze the Y chromosome microdeletions in the family of the infertile male and to study on the vertical transmission of Y chromosome microdeletions from father to son.</p><p><b>METHODS</b>The peripheral blood of infertile patients' family male members was extracted and analyzed with modified multiplex PCR. The infertile family tree was drawn according to the results.</p><p><b>RESULTS</b>Two cases in twelve investigated families had azoospermia factor (AZFc) microdeletion heredity. The others had no heredity.</p><p><b>CONCLUSION</b>AZFc microdeletion of the Y chromosome can be transmitted to the male offspring naturally,and the same deletion can result in different phenotypes in different individuals.</p>
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Linhagem
/
Saúde da Família
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Deleção Cromossômica
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Cromossomos Humanos Y
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Azoospermia
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Genética
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Infertilidade Masculina
Limite:
Adult
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Aged
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Female
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Humans
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Male
Idioma:
Zh
Revista:
Chinese Journal of Medical Genetics
Ano de publicação:
2007
Tipo de documento:
Article