Significance of p53 gene mutation and P53 protein expression abnormality on the prognosis of esophageal cancer: a meta-analysis study / 中华流行病学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To evaluate the prognostic significance of p53 mutation and P53 protein expression abnormality among esophageal cancer.</p><p><b>METHODS</b>The results of 27 random controlled trials from 1990 to 2003 were analyzed by meta-analysis method. The overall positive rate of p53 was 52.9% among the cumulative 2174 cases. Relative hazard (RH) was applied to evaluate the risk of disease and all data were analyzed by Dersimonian-Laird method.</p><p><b>RESULTS</b>The analysis for homogeneity (q statistics test) showed that all eligible studies were with heterogeneity (q = 59.88, P < 0.005). The combined RH was 2.07 and 95% confidence interval was 1.58-2.70.</p><p><b>CONCLUSION</b>Findings showed that p53 was a poor prognosis biomarker for esophageal cancer gene diagnosis but might benefit to the strategy of treatment.</p>