The spontaneous YMDD mutation rate in chronic hepatitis B patients / 中华肝脏病杂志
Chinese Journal of Hepatology
;
(12): 887-890, 2009.
Artigo
em Chinês
| WPRIM
| ID: wpr-247634
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the spontaneous YMDD mutation rate.</p><p><b>METHODS</b>Serum samples collected from 196 untreated chronic HBV patients were detected by primer-specific real-time PCR.</p><p><b>RESULTS</b>Among 196 patients, spontaneous YMDD variants were detected in 21 subjects (20 YVDD mutants and 1 YIDD mutant). YMDD variants account for more than 50%, 25% to 50%, 9% to 25% of total virus load in 1, 5 and 15 patients, respectively. Gender, age, HBeAg status, serum viral load, the state of disease and duration of infection were not associated with spontaneous YMDD mutation. Genotype B had higher spontaneous YMDD rate than genotype C (20.00% vs 7.38%, x(2) = 6.28, P < 0.05).</p><p><b>CONCLUSION</b>Spontaneous YMDD variants exist in chronic hepatitis B patients, Genotype B is associated with higher spontaneous YMDD rate.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Virologia
/
Sangue
/
DNA Viral
/
Vírus da Hepatite B
/
Reação em Cadeia da Polimerase
/
Sensibilidade e Especificidade
/
Primers do DNA
/
Carga Viral
/
Hepatite B Crônica
/
Genética
Tipo de estudo:
Estudo diagnóstico
Limite:
Adolescente
/
Adulto
/
Idoso
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Hepatology
Ano de publicação:
2009
Tipo de documento:
Artigo
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