Analysis of PAX6 gene mutations in a Chinese family affected with congenital aniridia / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 523-525, 2016.
Artigo
em Chinês
| WPRIM
| ID: wpr-247642
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the mutation of PAX6 gene in a Chinese family affected with congenital aniridia.</p><p><b>METHODS</b>Blood samples were drawn from family members, and DNA was analyzed by direct sequencing.</p><p><b>RESULTS</b>A heterozygous mutation (c.151 G>A) was identified in the PAX6 gene in the proband and other patients from the family. The same mutation was not found among unaffected family members and 160 unrelated healthy controls.</p><p><b>CONCLUSION</b>A novel mutation in the PAX6 gene has been identified in a Chinese family affected with aniridia.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Proteínas Repressoras
/
Aniridia
/
Proteínas de Homeodomínio
/
Fatores de Transcrição Box Pareados
/
Proteínas do Olho
/
Fator de Transcrição PAX6
/
Genética
/
Mutação
Tipo de estudo:
Estudo prognóstico
Limite:
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Medical Genetics
Ano de publicação:
2016
Tipo de documento:
Artigo
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