Effect of perioperative glucose-insulin-potassium infusions on the prognosis in patients undergoing coronary artery bypass grafting: a meta-analysis / 中华外科杂志
Chinese Journal of Surgery
;
(12): 1021-1026, 2012.
Artigo
em Chinês
| WPRIM
| ID: wpr-247918
ABSTRACT
<p><b>OBJECTIVE</b>To assess the effect of perioperative glucose-insulin-potassium (GIK) infusions on the prognosis in patients undergoing coronary artery bypass grafting.</p><p><b>METHODS</b>Electronic databases including Cochrane library (Issue 3, 2011), Pubmed, EMbase, Highwire, CBM and CNKI were searched. A meta-analysis of all randomized controlled trials (RCTs) comparing GIK with control in coronary artery bypass grafting was performed. Study selection and meta-analysis were conducted which according to the Cochrane Handbook for systematic reviews. Date were extracted from these trials by 3 reviewers independently and analyzed by RevMan5.0 software.</p><p><b>RESULTS</b>A total of 9 RCTs including 1029 patients were assessed in this study. GIK infusion was associated with significantly fewer perioperative myocardial infarctions (RR = 0.59, 95%CI 0.38 - 0.91, P = 0.02), less inotropic support requirement (RR = 0.44, 95%CI 0.35 - 0.56, P < 0.01), and increase the incidence of postoperative atrial fibrillation (RR = 1.23, 95%CI 1.05 - 1.43, P = 0.009).</p><p><b>CONCLUSIONS</b>GIK significantly reduces myocardial injury and improves cardiac function in patients undergoing coronary artery bypass grafting, but also increases the incidence of postoperative atrial fibrillation.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Período Pós-Operatório
/
Potássio
/
Prognóstico
/
Ensaios Clínicos Controlados Aleatórios como Assunto
/
Ponte de Artéria Coronária
/
Glucose
/
Insulina
/
Infarto do Miocárdio
Tipo de estudo:
Ensaio Clínico Controlado
/
Estudo prognóstico
/
Revisões Sistemáticas Avaliadas
Limite:
Humanos
Idioma:
Chinês
Revista:
Chinese Journal of Surgery
Ano de publicação:
2012
Tipo de documento:
Artigo
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