Impact of stages of axillary lymph nodes and pathological response to neoadjuvant chemotherapy on the survival of breast cancer patients / 中华肿瘤杂志
Chinese Journal of Oncology
;
(12): 195-199, 2015.
Artigo
em Chinês
| WPRIM
| ID: wpr-248384
ABSTRACT
<p><b>OBJECTIVE</b>To analyze the relevance between lymph node status and pathological response after neoadjuvant chemotherapy and survival in breast cancer patients.</p><p><b>METHODS</b>The clinicopathological data of 653 needle biopsy proved breast cancer patients, who underwent neoadjuvant chemotherapy and surgery in our hospital from July 1998 to April 2012, were retrospective analyzed.</p><p><b>RESULTS</b>The median follow up time was 59.3 months. The 653 cases were classified into ypN0 (242 cases), ypN1 (182 cases), ypN2 (135 cases), and ypN3 (94 cases) stages, and the 5-year overall survival rates in the four groups were 93.4%, 93.4%, 87.4%, and 83.0%, respectively. The Log rank test showed a significant difference in the overall survival rates between the ypN0, ypN1, ypN2 stages and ypN3 stage (P=0.046). No significant differences were observed between the disease free survival (DFS) rates in the four groups (P>0.05). Multivariate analysis indicated that the postoperative pathological response of metastatic lymph nodes was a major prognostic factor affecting the overall survival and disease-free survival (RR=1.051, P=0.007; RR=1.028, P=0.028).</p><p><b>CONCLUSION</b>The stage and pathological response of axillary lymph nodes after neoadjuvant chemotherapy are effective indicators for predicting the OS and DFS in breast cancer patients.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Prognóstico
/
Axila
/
Neoplasias da Mama
/
Taxa de Sobrevida
/
Estudos Retrospectivos
/
Intervalo Livre de Doença
/
Terapia Neoadjuvante
/
Tratamento Farmacológico
/
Linfonodos
/
Metástase Linfática
Tipo de estudo:
Estudo observacional
/
Estudo prognóstico
Limite:
Feminino
/
Humanos
Idioma:
Chinês
Revista:
Chinese Journal of Oncology
Ano de publicação:
2015
Tipo de documento:
Artigo
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